The icon of the Mother of God which is known as the "Sign" depicts the Most Holy Theotokos seated, with her hands raised in prayer. Depicted upon a round shield or sphere, upon her breast, is the Divine Infant - the Saviour-Emmanuel - in an attitude of blessing. Such a representation is of a type manifested in the very earliest iconographic depictions of the Theotokos. In the tomb of Saint Agnia in Rome, the Theotokos is depicted with arms extended in prayer, and with the Infant seated on her knees.