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Chapter 2. Review of Basic Principles of Pharmacology

Multiple Choice

Identify the choice that best completes the statement or answers the question.

____ 1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to prescribing because:

1.	Distribution of drugs to target tissue may be affected.
2.	The solubility of the drug will not match the site of absorption.
3.	There will be less free drug available to generate an effect.
4.	Drugs bound to albumin are readily excreted by the kidneys.

____ 2. Drugs that have a significant first-pass effect:

1.	Must be given by the enteral (oral) route only
2.	Bypass the hepatic circulation
3.	Are rapidly metabolized by the liver and may have little if any desired action
4.	Are converted by the liver to more active and fat-soluble forms

____ 3. The route of excretion of a volatile drug will likely be the:

1.	Kidneys
2.	Lungs
3.	Bile and feces
4.	Skin

____ 4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to create a storage reservoir of the drug. Storage reservoirs:

1.	Assure that the drug will reach its intended target tissue
2.	Are the reason for giving loading doses
3.	Increase the length of time a drug is available and active
4.	Are most common in collagen tissues

____ 5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:

1.	Propensity to go to the target receptor
2.	Biological half-life
3.	Pharmacodynamics
4.	Safety and side effects

____ 6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the prescription. This is considered a loading dose. A loading dose:

1.	Rapidly achieves drug levels in the therapeutic range
2.	Requires four- to five-half-lives to attain
3.	Is influenced by renal function
4.	Is directly related to the drug circulating to the target tissues

____ 7. The point in time on the drug concentration curve that indicates the first sign of a

About this item

Chapter 2. Review of Basic Principles of Pharmacology

Multiple Choice

Identify the choice that best completes the statement or answers the question.

____ 1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to prescribing because:

1.	Distribution of drugs to target tissue may be affected.
2.	The solubility of the drug will not match the site of absorption.
3.	There will be less free drug available to generate an effect.
4.	Drugs bound to albumin are readily excreted by the kidneys.

____ 2. Drugs that have a significant first-pass effect:

1.	Must be given by the enteral (oral) route only
2.	Bypass the hepatic circulation
3.	Are rapidly metabolized by the liver and may have little if any desired action
4.	Are converted by the liver to more active and fat-soluble forms

____ 3. The route of excretion of a volatile drug will likely be the:

1.	Kidneys
2.	Lungs
3.	Bile and feces
4.	Skin

____ 4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to create a storage reservoir of the drug. Storage reservoirs:

1.	Assure that the drug will reach its intended target tissue
2.	Are the reason for giving loading doses
3.	Increase the length of time a drug is available and active
4.	Are most common in collagen tissues

____ 5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:

1.	Propensity to go to the target receptor
2.	Biological half-life
3.	Pharmacodynamics
4.	Safety and side effects

____ 6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the prescription. This is considered a loading dose. A loading dose:

1.	Rapidly achieves drug levels in the therapeutic range
2.	Requires four- to five-half-lives to attain
3.	Is influenced by renal function
4.	Is directly related to the drug circulating to the target tissues

____ 7. The point in time on the drug concentration curve that indicates the first sign of a

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About this item

Chapter 2. Review of Basic Principles of Pharmacology

Multiple Choice

Identify the choice that best completes the statement or answers the question.

____ 1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to prescribing because:

1.	Distribution of drugs to target tissue may be affected.
2.	The solubility of the drug will not match the site of absorption.
3.	There will be less free drug available to generate an effect.
4.	Drugs bound to albumin are readily excreted by the kidneys.

____ 2. Drugs that have a significant first-pass effect:

1.	Must be given by the enteral (oral) route only
2.	Bypass the hepatic circulation
3.	Are rapidly metabolized by the liver and may have little if any desired action
4.	Are converted by the liver to more active and fat-soluble forms

____ 3. The route of excretion of a volatile drug will likely be the:

1.	Kidneys
2.	Lungs
3.	Bile and feces
4.	Skin

____ 4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to create a storage reservoir of the drug. Storage reservoirs:

1.	Assure that the drug will reach its intended target tissue
2.	Are the reason for giving loading doses
3.	Increase the length of time a drug is available and active
4.	Are most common in collagen tissues

____ 5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:

1.	Propensity to go to the target receptor
2.	Biological half-life
3.	Pharmacodynamics
4.	Safety and side effects

____ 6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the prescription. This is considered a loading dose. A loading dose:

1.	Rapidly achieves drug levels in the therapeutic range
2.	Requires four- to five-half-lives to attain
3.	Is influenced by renal function
4.	Is directly related to the drug circulating to the target tissues

____ 7. The point in time on the drug concentration curve that indicates the first sign of a

About this item

Chapter 2. Review of Basic Principles of Pharmacology

Multiple Choice

Identify the choice that best completes the statement or answers the question.

____ 1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical to prescribing because:

1.	Distribution of drugs to target tissue may be affected.
2.	The solubility of the drug will not match the site of absorption.
3.	There will be less free drug available to generate an effect.
4.	Drugs bound to albumin are readily excreted by the kidneys.

____ 2. Drugs that have a significant first-pass effect:

1.	Must be given by the enteral (oral) route only
2.	Bypass the hepatic circulation
3.	Are rapidly metabolized by the liver and may have little if any desired action
4.	Are converted by the liver to more active and fat-soluble forms

____ 3. The route of excretion of a volatile drug will likely be the:

1.	Kidneys
2.	Lungs
3.	Bile and feces
4.	Skin

____ 4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to create a storage reservoir of the drug. Storage reservoirs:

1.	Assure that the drug will reach its intended target tissue
2.	Are the reason for giving loading doses
3.	Increase the length of time a drug is available and active
4.	Are most common in collagen tissues

____ 5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:

1.	Propensity to go to the target receptor
2.	Biological half-life
3.	Pharmacodynamics
4.	Safety and side effects

____ 6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the prescription. This is considered a loading dose. A loading dose:

1.	Rapidly achieves drug levels in the therapeutic range
2.	Requires four- to five-half-lives to attain
3.	Is influenced by renal function
4.	Is directly related to the drug circulating to the target tissues

____ 7. The point in time on the drug concentration curve that indicates the first sign of a

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