JANEWAY'S IMMUNOBIOLOGY, 9
TH EDITION
CHAPTER 1: BASIC CONCEPTS IN IMMUNOLOGY
The origins of vertebrate immune cells
1.1 Multiple choice: In patients with lymphomas, the cancer cells invade the bone marrow
and destroy the environment required for normal hematopoiesis. This leads to bone
marrow failure, which disrupts the production of hematopoietic cell lineages. All of the
following cell types would be affected by this EXCEPT:
A. Red blood cells
B. Macrophages
C. Lymphocytes
D. Endothelial cells
E. Granulocytes
Principles of innate immunity
1-1 Commensal organisms cause little host damage while pathogens damage host
tissues by a variety of mechanisms
1.2 True/False: Our immune system efficiently kills all categories of microbes that attempt to
colonize our bodies.
1.3 Short answer: Pathogenic orga
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e to the host by a variety of
mechanisms, depending on the category of the pathogen and its mode of replication in
the host. Give an example of two different types of pathogens that are unlikely to be
dealt with by the same mechanism of immune protection.
1-2 Anatomic and chemical barriers are the first defense against pathogens
1.4 Multiple choice: The skin and bodily secretions provide the first line of defense against
infection. One response in this category that is common during upper respiratory virus
infections is:
A. Production of antibodies
B. Infiltration by white blood cells
C. Mucus production
D. Increased saliva production
E. Fever
1-3 The immune system is activated by inflammatory inducers that indicate the presence
of pathogens or tissue damage
1.5 Short answer: A common mechanism by which sensor cells in the host detect microorganisms relies on the production of unique microbial components not found in the
host. Propose a strategy by which a clever microbe could evade this type of response.
1.6 Multiple choice: Adaptive immune responses are slow to develop, taking days to weeks
after exposure to reach their peak. However, these responses are more specific than
innate responses, and also generate immunological memory. These latter features,