Saint Innocent, Bishop of Irkutsk, (in the world John) was descended from the noble Kulchitsky family. His parents moved from Volhynia to the Chernigov region in the mid-seventeenth century. The saint was born in about the year 1680, and educated at the Kiev Spiritual Academy. He accepted monastic tonsure in 1710 and was appointed an instructor at the Moscow Slavonic-Greek-Latin Academy as prefect and professor of theology.

In 1719 St Innocent transferred to the St Peterburg Alexander Nevsky Lavra, and was appointed chief naval chaplain. In 1720 he served as vice-regent of the Alexander Nevsky Lavra.