Saint Maximus the Greek was the son of a rich Greek dignitary in the city of Arta (Epiros), and he received a splendid education. In his youth he travelled widely and he studied languages and sciences (i.e. intellectual disciplines) in Europe, spending time in Paris, Florence, and Venice.

Upon returning to his native land, he went to Athos and became a monk at the Vatopedi monastery. And with enthusiasm he studied ancient manuscripts left on Athos by the Byzantine Emperors Andronicus Paleologos and John Kantakuzenos (who became monks).

During this period the Moscow Great Prince Basil III (1505-1533) wanted to make an inventory of the Greek manuscripts and books of his mother, Sophia Paleologina, and he asked the Protos of the Holy Mountain, Igumen Simeon, to send him a translator.